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The next extra adverse reactions have been claimed with the topical utilization of metronidazole: transient redness, metallic style, tingling or numbness of extremities, and nausea.

There won't be any details on the effects of metronidazole on milk output. Due to opportunity for really serious adverse reactions, advise clients that breastfeeding is not encouraged during remedy with METROGEL.

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The readily available facts will not allow the calculation of appropriate comparisons involving the systemic exposures of metronidazole observed in animal scientific studies for the systemic exposures that would be envisioned in people soon after topical use of METROGEL.

Precise experiments of metronidazole levels in human milk next intravaginally administered metronidazole have not been carried out. Nonetheless, metronidazole is secreted in human milk in concentrations much like All those found in jnetoto plasma jnetoto following oral administration of metronidazole.

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No fetotoxicity was noticed immediately after oral metronida-zole in rats or mice. Nevertheless, simply because animal replica studies will not be generally predictive of human reaction and due to the fact oral metron-idazole has actually been demonstrated to be a carcinogen in a few rodents, this drug jnetoto needs to be made use of for the duration of pregnancy only if Evidently required.

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